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Article

Orbital fibroblast heterogeneity may determine the clinical presentation of thyroid-associated ophthalmopathy.

The Journal of clinical endocrinology and metabolism - 1 Jan 2002

Smith Terry J, Koumas Laura, Gagnon AnneMarie, Bell Andrea, Sempowski Gregory D, Phipps Richard P, Sorisky Alexander

Abstract excerpt

Thyroid-associated ophthalmopathy, a process in which the orbital tissues become inflamed and are remodeled, occurs with a variable presentation. In some patients, eye muscle enlargement predominates. In others, the connective/adipose tissue enlargement appears the more significant problem. Orbital fibroblasts exhibit heterogeneous phenotypes in culture. Here we report that fibroblasts derived from the...

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Identifiers

PMID: 11788681
DOI: 10.1210/jcem.87.1.8164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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