scabrous modifies epithelial cell adhesion and extends the range of lateral signalling during development of the spaced bristle pattern in Drosophila.

Abstract excerpt

The role of scabrous (sca) in the evenly spaced bristle pattern of Drosophila is explored. Loss-of-function of sca results in development of an excess of bristles. Segregation of alternately spaced bristle precursors and epidermal cells from a group of equipotential cells relies on lateral inhibition mediated by Notch and Delta (Dl). In this process, presumptive bristle precursors inhibit the neural fate of...

Topics

• Animals
• Animals, Genetically Modified
• Body Patterning
• Cadherins
• Cell Adhesion
• Drosophila
• Drosophila Proteins
• Epithelial Cells
• Female
• Gene Expression Regulation, Developmental
• Genes, Insect
• Glycoproteins
• Insect Proteins
• Intracellular Signaling Peptides and Proteins
• Male
• Membrane Proteins
• Microscopy, Electron
• Mutation