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Article

Functional analysis of the fibrinogen-related scabrous gene from Drosophila melanogaster identifies potential effector and stimulatory protein domains.

Genetics - 1 Oct 1998

Lee E C, Yu S Y, Hu X, Mlodzik M, Baker N E

Abstract excerpt

The scabrous (sca) gene encodes a secreted dimeric glycoprotein with putative coiled-coil domains N-terminally and a C-terminal region related to the blood clot protein fibrinogen. Homozygous sca mutants have extra bristle organs and rough eyes. We describe a GAL4-based expression system for testing rescue of the sca mutant phenotype by altered SCA proteins and for misexpression. We find that deletion of the...

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Identifiers

PMID: 9755198
DOI: 10.1093/genetics/150.2.663
PMCID: PMC1460338

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