Article
Modulation of the Ras/MAPK signalling pathway by the redox function of selenoproteins in Drosophila melanogaster.
Developmental biology - 1 Oct 2001
Morey M, Serras F, Baguñà J, Hafen E, Corominas M
Abstract excerpt
Modulation of reactive oxygen species (ROS) plays a key role in signal transduction pathways. Selenoproteins act controlling the redox balance of the cell. We have studied how the alteration of the redox balance caused by patufet (selD(ptuf)), a null mutation in the Drosophila melanogaster selenophosphate synthetase 1 (sps1) gene, which codes for the SelD enzyme of the selenoprotein biosynthesis, affects the...
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