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Enhancing autophagy by redox regulation extends lifespan in Drosophila

25 Jun 2025

Abstract excerpt

Abstract Dysregulation of redox homeostasis is implicated in the ageing process and the pathology of age-related diseases. To study redox signalling by H2O2 in vivo, we established a redox-shifted model by manipulating levels of the H2O2-degrading enzyme catalase in Drosophila. Here we report that ubiquitous over-expression of catalase robustly extends lifespan in females. As anticipated, these flies are strongly...

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PMID: 40562835
DOI: 10.1038/s41467-025-60603-w

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