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Article

Effect of merlin phosphorylation on neurofibromatosis 2 (NF2) gene function.

Oncogene - 15 Jan 2004

Surace Ezequiel I, Haipek Carrie A, Gutmann David H

Abstract excerpt

The neurofibromatosis 2 (NF2) tumor suppressor gene product, merlin, belongs to the ezrin-radixin-moesin (ERM) subgroup of the Protein 4.1 family, which links cell surface glycoproteins to the actin cytoskeleton. Previous studies have suggested that phosphorylation of merlin, similar to other ERM proteins, may regulate its function. To determine whether merlin phosphorylation has functional consequences for...

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Source

Identifiers

PMID: 14724586
DOI: 10.1038/sj.onc.1207142

Genes

NF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Effect of merlin phosphorylation on neurofibromatosis 2 (NF2) gene function.PMID 14724586Read ↗

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p21-activated Kinase Links Rac/Cdc42 Signaling to MerlinSemantic proximity Read ↗

Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesionand spreading.Semantic proximity Read ↗

Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival.Semantic proximity Read ↗

Shedding light on Merlin's wizardry.Semantic proximity Read ↗

Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization.Semantic proximity Read ↗

Structural Analysis of Drosophila Merlin Reveals Functional Domains Important for Growth Control and Subcellular LocalizationSemantic proximity Read ↗

<i>NF2</i>: The wizardry of merlinSemantic proximity Read ↗

NF2/Merlin Inactivation and Potential Therapeutic Targets in Mesothelioma.Semantic proximity Read ↗

Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression.Semantic proximity Read ↗

The tumor suppressor merlin interacts with microtubules and modulates Schwann cell microtubule cytoskeletonSemantic proximity Read ↗

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