Article
Effect of merlin phosphorylation on neurofibromatosis 2 (NF2) gene function.
Oncogene - 15 Jan 2004
Surace Ezequiel I, Haipek Carrie A, Gutmann David H
Abstract excerpt
The neurofibromatosis 2 (NF2) tumor suppressor gene product, merlin, belongs to the ezrin-radixin-moesin (ERM) subgroup of the Protein 4.1 family, which links cell surface glycoproteins to the actin cytoskeleton. Previous studies have suggested that phosphorylation of merlin, similar to other ERM proteins, may regulate its function. To determine whether merlin phosphorylation has functional consequences for...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- Cell Division
- Cell Line, Tumor
- Cell Movement
- Genes, Neurofibromatosis 2
- Humans
- Molecular Sequence Data
- Mutation
- Neurofibromatosis 2