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Article

The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements.

The EMBO journal - 15 Jan 2002

Mukherjee Devi, Gao Min, O'Connor J Patrick, Raijmakers Reinout, Pruijn Ger, Lutz Carol S, Wilusz Jeffrey

Abstract excerpt

HeLa cytoplasmic extracts contain both 3'-5' and 5'-3' exonuclease activities that may play important roles in mRNA decay. Using an in vitro RNA deadenylation/decay assay, mRNA decay intermediates were trapped using phosphothioate-modified RNAs. These data indicate that 3'-5' exonucleolytic decay is the major pathway of RNA degradation following deadenylation in HeLa cytoplasmic extracts. Immunodepletion using...

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Identifiers

PMID: 11782436
DOI: 10.1093/emboj/21.1.165
PMCID: PMC125812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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