Article
Efficient oligonucleotide-mediated degradation of nuclear noncoding RNAs in mammalian cultured cells.
RNA (New York, N.Y.) - 1 Aug 2009
Ideue Takashi, Hino Kimihiro, Kitao Saori, Yokoi Takahide, Hirose Tetsuro
Abstract excerpt
Recent large-scale transcriptome analyses have revealed that large numbers of noncoding RNAs (ncRNAs) are transcribed from mammalian genomes. They include small nuclear RNAs (snRNAs), small nucleolar RNAs (snoRNAs), and longer ncRNAs, many of which are localized to the nucleus, but which have remained functionally elusive. Since ncRNAs are only known to exist in mammalian species, established experimental...
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