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Article

Crystal structure of reovirus attachment protein sigma1 reveals evolutionary relationship to adenovirus fiber.

The EMBO journal - 15 Jan 2002

Chappell James D, Prota Andrea E, Dermody Terence S, Stehle Thilo

Abstract excerpt

Reovirus attaches to cellular receptors with the sigma1 protein, a fiber-like molecule protruding from the 12 vertices of the icosahedral virion. The crystal structure of a receptor-binding fragment of sigma1 reveals an elongated trimer with two domains: a compact head with a new beta-barrel fold and a fibrous tail containing a triple beta-spiral. Numerous structural and functional similarities between reovirus...

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Share to Adenoviridae
Share to Cell Adhesion Molecules
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Conformation

Share to Receptors, Virus

Share to Reoviridae

Share to Sequence Homology, Amino Acid

Share to Viral Nonstructural Proteins

Source

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Identifiers

PMID: 11782420
DOI: 10.1093/emboj/21.1.1
PMCID: PMC125343

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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