Article
Junction adhesion molecule is a receptor for reovirus.
Cell - 9 Feb 2001
Barton E S, Forrest J C, Connolly J L, Chappell J D, Liu Y, Schnell F J, Nusrat A, Parkos C A, Dermody T S
Abstract excerpt
Virus attachment to cells plays an essential role in viral tropism and disease. Reovirus serotypes 1 and 3 differ in the capacity to target distinct cell types in the murine nervous system and in the efficiency to induce apoptosis. The binding of viral attachment protein sigma1 to unidentified receptors controls these phenotypes. We used expression cloning to identify junction adhesion molecule (JAM), an integral...
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