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A Structural Perspective on the Alphavirus Life Cycle

28 Jul 2025

Abstract excerpt

Alphaviruses are mosquito-borne, enveloped viruses with a positive-sense, single-stranded RNA genome. Alphaviruses enter host cells via receptor-mediated endocytosis, using various cellular surface receptors such as matrix remodeling-associated protein 8 (MXRA8), low-density lipoprotein receptor class A domain-containing 3 (LDLRAD3), and very low-density lipoprotein receptor (VLDLR), which facilitate binding to...

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PMID: 40720808
DOI: 10.1146/annurev-virology-093022-010359

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