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Article

Optimum length and flexibility of reovirus attachment protein σ1 are required for efficient viral infection.

Journal of virology - 1 Oct 2012

Bokiej Magdalena, Ogden Kristen M, Ikizler Mine, Reiter Dirk M, Stehle Thilo, Dermody Terence S

Abstract excerpt

Reovirus attachment protein σ1 is an elongated trimer with head-and-tail morphology that engages cell-surface carbohydrate and junctional adhesion molecule A (JAM-A). The σ1 protein is comprised of three domains partitioned by two flexible linkers termed interdomain regions (IDRs). To determine the importance of σ1 length and flexibility at different stages of reovirus infection, we generated viruses with mutant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22811534
DOI: 10.1128/JVI.01338-12
PMCID: PMC3457286

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