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Article

Identification of novel polymorphisms in the beta7 integrin gene: family-based association studies in inflammatory bowel disease.

Genes and immunity - 1 Dec 2001

van Heel D A, Carey A H, Jewell D P

Abstract excerpt

Linkage studies from five groups worldwide have confirmed the presence of an inflammatory bowel disease susceptibility locus on chromosome 12q. Beta 7 integrin is a strong candidate gene within this region, and is involved in lymphocyte homing to the gut and retention of intra-epithelial lymphocytes. Monoclonal antibodies to beta7 integrin ameliorate colitis in animal models. We obtained genomic sequence for...

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Identifiers

PMID: 11781713
DOI: 10.1038/sj.gene.6363810

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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