Article
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
Nature genetics - 1 Feb 2017
de Lange Katrina M, Moutsianas Loukas, Lee James C, Lamb Christopher A, Luo Yang, Kennedy Nicholas A, Jostins Luke, Rice Daniel L, Gutierrez-Achury Javier, Ji Sun-Gou, Heap Graham, Nimmo Elaine R, Edwards Cathryn, Henderson Paul, Mowat Craig, Sanderson Jeremy, Satsangi Jack, Simmons Alison, Wilson David C, Tremelling Mark, Hart Ailsa, Mathew Christopher G, Newman William G, Parkes Miles, Lees Charlie W, Uhlig Holm, Hawkey Chris, Prescott Natalie J, Ahmad Tariq, Mansfield John C, Anderson Carl A, Barrett Jeffrey C
Abstract excerpt
Genetic association studies have identified 215 risk loci for inflammatory bowel disease, thereby uncovering fundamental aspects of its molecular biology. We performed a genome-wide association study of 25,305 individuals and conducted a meta-analysis with published summary statistics, yielding a total sample size of 59,957 subjects. We identified 25 new susceptibility loci, 3 of which contain integrin genes that...
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