Article
Integrin alpha 7 beta 1 in muscular dystrophy/myopathy of unknown etiology.
The American journal of pathology - 1 Jun 2002
Pegoraro Elena, Cepollaro Fulvio, Prandini Paola, Marin Alessandra, Fanin Marina, Trevisan Carlo P, El-Messlemani Abdul Hassib, Tarone Guido, Engvall Eva, Hoffman Eric P, Angelini Corrado
Abstract excerpt
To investigate the role of integrin alpha 7 in muscle pathology, we used a "candidate gene" approach in a large cohort of muscular dystrophy/myopathy patients. Antibodies against the intracellular domain of the integrin alpha 7A and alpha 7B were used to stain muscle biopsies from 210 patients with muscular dystrophy/myopathy of unknown etiology. Levels of alpha 7A and alpha 7B integrin were found to be decreased...
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