Article
HLA-DR, HLA-DQ, and TAP genes in familial Hodgkin disease.
Blood - 15 Jan 2002
Harty Lea C, Lin Albert Y, Goldstein Alisa M, Jaffe Elaine S, Carrington Mary, Tucker Margaret A, Modi William S
Abstract excerpt
The HLA region has long been implicated in sporadic and familial Hodgkin disease (HD), with recent case-control studies suggesting that HLA class II loci predispose to sporadic nodular sclerosis HD (NSHD). To determine whether this predisposition extends to familial HD, HLA class II loci (DRB1, DQA1, DQB1, DRB3, DRB4, and DRB5) and transporter associated with antigen processing (TAP) loci (TAP1, TAP2) were...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 2
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Adolescent
- Adult
- Alleles
- Child
- Female
- Gene Frequency
- Genes, MHC Class II
- Genetic Predisposition to Disease
- Genotype
- HLA-DQ Antigens
- HLA-DR Antigens
- Hodgkin Disease
- Humans
- Linkage Disequilibrium
- Male