Article
HLA-A*02 is associated with a reduced risk and HLA-A*01 with an increased risk of developing EBV+ Hodgkin lymphoma.
Blood - 1 Nov 2007
Niens Marijke, Jarrett Ruth F, Hepkema Bouke, Nolte Ilja M, Diepstra Arjan, Platteel Mathieu, Kouprie Niels, Delury Craig P, Gallagher Alice, Visser Lydia, Poppema Sibrand, te Meerman Gerard J, van den Berg Anke
Abstract excerpt
Previous studies showed that the HLA class I region is associated with Epstein-Barr virus (EBV)-positive Hodgkin lymphoma (HL) and that HLA-A is the most likely candidate gene in this region. This suggests that antigenic presentation of EBV-derived peptides in the context of HLA-A is involved in...
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