Article
Antigen presenting phenotype of Hodgkin Reed-Sternberg cells: analysis of the HLA class I processing pathway and the effects of interleukin-10 on epstein-barr virus-specific cytotoxic T-cell recognition.
Blood - 1 Aug 1998
Lee S P, Constandinou C M, Thomas W A, Croom-Carter D, Blake N W, Murray P G, Crocker J, Rickinson A B
Abstract excerpt
Approximately 40% of Hodgkin's disease (HD) cases in Western countries carry Epstein-Barr virus (EBV) in the malignant Hodgkin-Reed-Sternberg (H-RS) cells. HLA class I-restricted cytotoxic T lymphocytes (CTLs) with specificity for viral antigens expressed in H-RS cells therefore have therapeutic...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 2
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Antigen Presentation
- Antigen-Presenting Cells
- Antigens, Viral
- Biopsy
- Epitopes
- Herpesviridae Infections
- Herpesvirus 4, Human
- Histocompatibility Antigens Class I
- Hodgkin Disease