Article
Association with HLA class I in Epstein-Barr-virus-positive and with HLA class III in Epstein-Barr-virus-negative Hodgkin's lymphoma.
Lancet (London, England) - 1 Jan 2000
Diepstra A, Niens M, Vellenga E, van Imhoff G W, Nolte I M, Schaapveld M, van der Steege G, van den Berg A, Kibbelaar R E, te Meerman G J, Poppema S
Abstract excerpt
BACKGROUND: Associations of Hodgkin's lymphoma with HLA have been reported for many years. In 20-40% of patients with this disorder, Epstein-Barr virus (EBV) is present in the neoplastic cells. Because presentation of EBV antigenic peptides can elicit vigorous immune responses, we investigated associations of the HLA region with EBV-positive and EBV-negative Hodgkin's lymphoma. METHODS: In a retrospective,...
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