Article
TAP 1 and TAP 2 transporter gene polymorphisms in multiple sclerosis: no evidence for disease association with TAP.
Journal of neuroimmunology - 1 Oct 1994
Vandevyver C, Stinissen P, Cassiman J J, Raus J
Abstract excerpt
Multiple sclerosis (MS) is known to be associated with HLA-DR2, but it is possible that additional major histocompatibility complex (MHC) genes confer disease susceptibility. The most recent candidate genes for MHC-encoded susceptibility are the TAP genes, which are located between the HLA-DQ and DP loci, and encode for proteins believed to transport antigenic peptides from the cytoplasm into the endoplasmic...
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