Article
HLA associations in classical Hodgkin lymphoma: EBV status matters.
PloS one - 1 Jan 2012
Huang Xin, Kushekhar Kushi, Nolte Ilja, Kooistra Wierd, Visser Lydia, Bouwman Ilby, Kouprie Niels, Veenstra Rianne, van Imhoff Gustaaf, Olver Bianca, Houlston Richard S, Poppema Sibrand, Diepstra Arjan, Hepkema Bouke, van den Berg Anke
Abstract excerpt
The pathogenesis of classical Hodgkin lymphoma (cHL) involves environmental and genetic factors. To explore the role of the human leukocyte antigen (HLA) genes, we performed a case-control genotyping study in 338 Dutch cHL patients using a PCR-based sequence-specific oligonucleotide probe (SSOP) hybridization approach. The allele frequencies were compared to HLA typings of more than 6,000 controls. The age of the...
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