Article
Localization of predisposition to Hodgkin disease in the HLA class II region.
American journal of human genetics - 1 Mar 1994
Klitz W, Aldrich C L, Fildes N, Horning S J, Begovich A B
Abstract excerpt
Molecular typing of HLA class II loci has been performed on a sample of 196 patients with Hodgkin lymphoma. Division of patients into two histological categories--nodular sclerosing Hodgkin disease versus all other types--shows significant overall association of the nodular sclerosing group with the HLA class II region. Haplotypes and alleles defined for the four loci typed--DRB1, DQA1, DQB1, and DPB1--were...
Topics
- Adolescent
- Adult
- Alleles
- Child
- Female
- Genes, MHC Class II
- Genetic Predisposition to Disease
- HLA-D Antigens
- HLA-DQ Antigens
- HLA-DR Antigens
- Haplotypes
- Histocompatibility Testing