Article
Interleukin-1RN gene polymorphisms in elderly patients with rheumatic inflammatory chronic conditions: Association of IL-1RN*2/2 genotype with polymyalgia rheumatica.
Human immunology - 1 Jan 2009
Alvarez-Rodriguez Lorena, Carrasco-Marin Eugenio, Lopez-Hoyos Marcos, Mata Cristina, Fernandez-Prieto Lorena, Ruiz-Soto Maria, Calvo Jaime, Rodriguez-Valverde Vicente, Ruiz Teresa, Blanco Ricardo, Corrales Alfonso, Martinez-Taboada Victor Manuel
Abstract excerpt
The objective of this study was to investigate whether there is an association between IL1RN polymorphism and disease susceptibility for three age-related inflammatory conditions: polymyalgia rheumatica (PMR), giant cell arteritis (GCA), and elderly-onset rheumatoid arthritis (EORA). A tandem-repeat polymorphism within IL1RN intron 2 was analyzed in 139 PMR, 69 GCA, and 156 RA patients (75 with EORA) as well as...
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