Article
HZE particle radiation induces tissue-specific and p53-dependent mutagenesis in transgenic animals.
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) - 1 Jan 2001
Chang P Y, Kanazawa N, Lutze-Mann L, Winegar R
Abstract excerpt
Transgenic animals, with the integrated target gene, provide a unique approach for measuring and characterizing mutations in any tissue of the animal. We are using the plasmid-based lacZ transgenic mice with different p53 genetic background to examine radiation-induced genetic damage resulting from exposure to heavy particle radiation. We measured lacZ mutation frequencies (MF) in the brain and spleen tissues at...
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