Development of early melanocytic lesions in transgenic mice predisposed to melanoma.

doi:10.1034/j.1600-0749.2000.130307.x

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Article

Development of early melanocytic lesions in transgenic mice predisposed to melanoma.

Pigment cell research - 1 Jun 2000

Zhu H, Reuhl K, Botha R, Ryan K, Wei J, Chen S

Abstract excerpt

We have previously described a line of transgenic mice (TG3) that spontaneously develops heritable malignant melanoma. Histological analysis of these animals during the first postnatal month is described here. In the TG3 line, the number of melanocytes is increased at all anatomical sites to which neural-crest-derived melanocytes normally migrate. Clonal expansion and morphological changes of these melanocytes...

Topics

Animals
Animals, Newborn
Anus Neoplasms
Ear Neoplasms
Eyelid Neoplasms
Genetic Predisposition to Disease
Levodopa
Melanocytes
Melanoma, Experimental
Mice
Mice, Transgenic
Neural Crest
Skin Neoplasms

Source

Open in PubMed

Identifiers

PMID: 10885674
DOI: 10.1034/j.1600-0749.2000.130307.x

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