Article
Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf-/- mice.
Archives of ophthalmology (Chicago, Ill. : 1960) - 1 Aug 2005
Tolleson William H, Doss Jason C, Latendresse John, Warbritton Alan R, Melchior William B, Chin Lynda, Dubielzig Richard R, Albert Daniel M
Abstract excerpt
OBJECTIVE: To characterize a murine model of spontaneous amelanotic melanoma arising in the uvea of transgenic mice bearing a targeted deletion of the Ink4a/Arf tumor suppressor locus (exons 2 and 3) and expressing human H-ras controlled by the human tyrosinase promoter. METHODS: Ocular lesions developed in 20 (15.7%) of 127 male albino Tyr-RAS+ Ink4a/Arf-/- transgenic FVB/N mice within 6 months, and were...
Topics
- Animals
- Biomarkers, Tumor
- Cyclin-Dependent Kinase Inhibitor p16
- Disease Models, Animal
- Gene Deletion
- Genes, ras
- Genotype
- Male
- Melanoma, Amelanotic
- Mice
- Mice, Transgenic