Article
Proficient mismatch repair protein expression in Hodgkin and Reed Sternberg cells.
International journal of cancer - 10 Jan 2002
Re Daniel, Benenson Lena, Wickenhauser Claudia, Starostik Petr, Staratschek-Jox Andrea, Müller-Hermelink Hans Konrad, Diehl Volker, Wolf Jürgen
Abstract excerpt
Hodgkin and Reed-Sternberg (H/RS) cells are characterized by chromosomal instability. Nevertheless, neither specific nor consistent chromosomal alterations could be characterized in H/RS cells. Microsatellite instability (MSI) is another form of genomic instability but its role in the pathogenesis of classical Hodgkin's disease (cHD) has not been investigated so far. We analyzed MSI and mismatch repair (MMR)...
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