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Article

Generation of Cells With Hodgkin’s and Reed-Sternberg Phenotype Through Downregulation of CD99 (Mic2)

1 Dec 1998

Abstract excerpt

Despite the fact that Hodgkin's and Reed-Sternberg (H-RS) cells are morphological hallmarks of Hodgkin's disease (HD), the nature of H-RS cells still remains to be resolved. Here we report that downregulation of CD99 (Mic2) leads to the generation of cells with an H-RS phenotype. IM9 and BJAB B-cell lines that were transfected with an antisense CD99 expression construct showed the morphological and immunological...

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Identifiers

PMID: 9834235
DOI: 10.1182/blood.v92.11.4287

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Generation of Cells With Hodgkin’s and Reed-Sternberg Phenotype Through Downregulation of CD99 (Mic2)PMID 9834235Read ↗

Viral latent membrane protein 1 (LMP-1)–induced CD99 down-regulation in B cells leads to the generation of cells with Hodgkin's and Reed-Sternberg phenotypeSemantic proximity Read ↗

Viral latent membrane protein 1 (LMP-1)–induced CD99 down-regulation in B cells leads to the generation of cells with Hodgkin's and Reed-Sternberg phenotypeSemantic proximity Read ↗

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