Article
P53 expression in Reed-Sternberg cells does not correlate with gene mutations in Hodgkin's disease.
American journal of clinical pathology - 1 Dec 1996
Elenitoba-Johnson K S, Medeiros L J, Khorsand J, King T C
Abstract excerpt
Immunohistochemically detectable p53 protein expression is common in the Reed-Sternberg and Hodgkin's (RS-H) cells of Hodgkin's disease, but p53 gene mutations have only rarely been identified. The authors found p53 expression in RS-H cells in 16 of 30 cases of Hodgkin's disease (53%), with the percentage of RS-H positive cells ranging from 4% to 85%. In 12 of 30 cases (40%), at least 10% of the RS-H cells were...
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