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Article

E4orf6 variants with separate abilities to augment adenovirus replication and direct nuclear localization of the E1B 55-kilodalton protein.

Journal of virology - 1 Feb 2002

Orlando Joseph S, Ornelles David A

Abstract excerpt

The E4orf6 protein of group C adenovirus is an oncoprotein that, in association with the E1B 55-kDa protein and by E1B-independent means, promotes virus replication. An arginine-faced amphipathic alpha-helix in the E4orf6 protein is required for the E4orf6 protein to direct nuclear localization of the E1B 55-kDa protein and to enhance replication of an E4 deletion virus. In this study, E4orf6 protein variants...

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Identifiers

PMID: 11773420
DOI: 10.1128/jvi.76.3.1475-1487.2002
PMCID: PMC135776

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