Article
Inefficient export of viral late mRNA contributes to fastidiousness of human adenovirus type 41 (HAdV-41) in 293 cells.
Virology - 1 Nov 2014
Zou Xiao-Hui, Li Wen-Jia, Guo Xiao-Juan, Qu Jian-Guo, Wang Min, Si Hong-Li, Lu Zhuo-Zhuang, Hung Tao
Abstract excerpt
The human adenovirus (HAdV) early protein E1B55K interacts with E4orf6 to form an E3 ubiquitin ligase complex, which plays key roles in virus replication. To illustrate the reason for the fastidiousness of HAdV-41 in 293 cells, interaction between heterotypic E1B55K and E4orf6 proteins was investigated. HAdV-5 E1B55K could interact with HAdV-41 E4orf6, and vice versa. To form E1B55K/E4orf6 E3 ubiquitin ligase,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
