Characterization of p53 mutants identified in human tumors with a missense mutation in the tetramerization domain.

doi:10.1002/(SICI)1097-0215(19981029)78:3<372::AID-IJC19>3.0.CO;2-8

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Article

Characterization of p53 mutants identified in human tumors with a missense mutation in the tetramerization domain.

International journal of cancer - 29 Oct 1998

Rollenhagen C, Chène P

Abstract excerpt

p53 is very often mutated in human cancers. The majority of alterations are missense mutations located within the DNA-binding domain of the protein. Many reports have characterized such mutant proteins. Little is known, however, about the properties of proteins that have a missense mutation outsi...

Topics

Amino Acid Substitution
Dimerization
Exons
Female
Genes, p53
Humans
Male
Mutation, Missense
Neoplasms
Phenotype
Protein Biosynthesis
Transfection
Tumor Cells, Cultured
Tumor Suppressor Protein p53

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