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Article

Phosphomimetic Mutation Destabilizes the Central Core Domain of Human p53.

IUBMB life - 1 Oct 2018

Luwang Johnson Wahengbam, Natesh Ramanathan

Abstract excerpt

Transcriptional activity of p53 is modulated by various posttranslational modifications. Earlier studies have reported that Aurora B phosphorylation of p53 leads to loss of its transcriptional activity, subsequently leading to its ubiquitin-mediated proteasomal degradation. To decipher the fate of structural and functional stature of p53 upon phosphorylation by Aurora B, we have generated five phosphomimetic...

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Identifiers

PMID: 30161293
DOI: 10.1002/iub.1914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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