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Article

Structure and functionality of a designed p53 dimer.

Journal of molecular biology - 23 Mar 2001

Davison T S, Nie X, Ma W, Lin Y, Kay C, Benchimol S, Arrowsmith C H

Abstract excerpt

P53 is a homotetrameric tumor suppressor protein involved in transcriptional control of genes that regulate cell proliferation and death. In order to probe the role that oligomerization plays in this capacity, we have previously designed and characterized a series of p53 proteins with altered oligomeric states through hydrophilc substitution of residues Met340 or Leu344 in the normally tetrameric oligomerization...

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Identifiers

PMID: 11254385
DOI: 10.1006/jmbi.2001.4450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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