Article
[Role of Wnt signaling and APC protein in the etiology of colorectal cancer].
Postepy higieny i medycyny doswiadczalnej - 1 Jan 2001
Cebrat M, Strzadała L
Abstract excerpt
In this paper we present recent data on molecular function of APC protein and Wnt signaling pathway. Role of a link between APC and Wnt signaling in the etiology of colorectal cancer as well as significance of a mutant APC mice as a model of cancer in man are discussed.
Topics
- Adenomatous Polyposis Coli Protein
- Animals
- Colorectal Neoplasms
- DNA Mutational Analysis
- DNA, Neoplasm
- Genes, APC
- Mice
- Mice, Mutant Strains
- Mitogens
- Models, Animal
- Mutation
- Proto-Oncogene Proteins
- Signal Transduction
