Article
[From gene to disease; the APC gene and familial adenomatous polyposis coli].
Nederlands tijdschrift voor geneeskunde - 14 Oct 2000
van der Luijt R B, Tops C M, Vasen H F
Abstract excerpt
Familial adenomatous polyposis coli is an autosomal dominant hereditary form of colorectal cancer associated with mutations in the adenomatous polyposis coli (APC) gene on chromosome 5. The APC protein is thought to mediate the stability of beta-catenin in the WNT signaling transduction pathway ('wingless-type mouse mammary tumor virus integration site family member') in normal colonic epithelial cells, thereby...
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