Article
Reciprocal congenic lines of mice capture the aliq1 effect on acute lung injury survival time.
American journal of respiratory cell and molecular biology - 1 Jan 2008
Prows Daniel R, Hafertepen Amanda P, Winterberg Abby V, Gibbons William J, Wesselkamper Scott C, Singer Jonathan B, Hill Annie E, Nadeau Joseph H, Leikauf George D
Abstract excerpt
Acute lung injury (ALI) is a devastating condition resulting from diverse causes. Genetic studies of human populations indicate that ALI is a complex disease with substantial phenotypic variance, incomplete penetrance, and gene-environment interactions. To identify genes controlling ALI mortality, we previously investigated mean survival time (MST) differences between sensitive A/J (A) and resistant C57BL/6J (B)...
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