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Article

The ionic layer is required for efficient dissociation of the SNARE complex by alpha-SNAP and NSF.

Proceedings of the National Academy of Sciences of the United States of America - 4 Dec 2001

Scales S J, Yoo B Y, Scheller R H

Abstract excerpt

The four-helical bundle soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor (SNARE) complex that mediates intracellular membrane fusion events contains a highly conserved ionic layer at the center of an otherwise hydrophobic core. This layer has an undetermined function; it consists of glutamine (Q) residues in syntaxin and the two synaptosomal-associated protein of 25 kDa...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11762430
DOI: 10.1073/pnas.251547598
PMCID: PMC64670

Genes

NSF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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