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Article

Mutation detection in tumor suppressor genes using archival tissue specimens.

Methods in molecular medicine - 1 Jan 2006

Astrinidis Aristotelis, Henske Elizabeth Petri

Abstract excerpt

Tuberous sclerosis complex (TSC) is a neurocutaneous syndrome characterized by seizures, mental retardation, and benign tumors of many organs, including the brain, kidneys, skin, retina, and heart. TSC is caused by mutations in the TSC1 and TSC2 tumor suppressor genes. The genes follow the two-hit model for tumorigenesis, with germline mutations inactivating one allele and somatic mutations inactivating the...

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Source

Identifiers

PMID: 16930013
DOI: 10.1385/1-59745-088-X:185

Genes

TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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