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Article

Xenophagy in herpes simplex virus replication and pathogenesis

1 Jan 2008

Abstract excerpt

Autophagy functions in part as an important host defense mechanism to engulf and degrade intracellular pathogens, a process that has been termed xenophagy. Xenophagy is detrimental to the invading microbe in terms of replication and pathogenesis and many pathogens either dampen the autophagic response, or utilize the pathway to enhance their life cycle. Herpes simplex virus type 1 (HSV-1) counteracts the...

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PMID: 18000391
DOI: 10.4161/auto.5222

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