Article
Epithelial polarity: interactions between junctions and apical-basal machinery.
Genetics - 1 Nov 2009
Kaplan Nicole A, Liu Xiaoping, Tolwinski Nicholas S
Abstract excerpt
Epithelial polarity is established and maintained by competition between determinants that define the apical and basolateral domains. Cell-cell adhesion complexes, or adherens junctions, form at the interface of these regions. Mutations in adhesion components as well as apical determinants normally lead to an expansion of the basolateral domain. Here we investigate the genetic relationship between the polarity...
Topics
- Animals
- Armadillo Domain Proteins
- Blotting, Western
- Cell Polarity
- Drosophila Proteins
- Drosophila melanogaster
- Embryo, Nonmammalian
- Epithelial Cells
- Female
- Fluorescent Antibody Technique
- Male
- Membrane Proteins
- Models, Biological
- Mutation
- Phenotype
- Protein Binding
- Transcription Factors
- Tumor Suppressor Proteins