Article
Phenotypic analysis of null mutants for DE-cadherin and Armadillo in Drosophila ovaries reveals distinct aspects of their functions in cell adhesion and cytoskeletal organization.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Jan 1997
Oda H, Uemura T, Takeichi M
Abstract excerpt
BACKGROUND: DE-cadherin is an epithelial cadherin in Drosophila, and forms adherens junctions by associating with Armadillo (beta-catenin). To investigate its role in oogenesis, we generated germ-line clones homozygous for a null mutation in shotgun (shg) encoding this molecule, and examined their phenotypes, comparing with those of armadillo (arm) mutants. RESULTS: In the wild-type ovaries, DE-cadherin was...
Topics
- Actins
- Animals
- Armadillo Domain Proteins
- Cadherins
- Cell Adhesion
- Cytoskeletal Proteins
- Cytoskeleton
- Drosophila
- Drosophila Proteins
- Female
- Homozygote
- Insect Proteins
- Mutation
- Oocytes
- Ovary