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Article

Abelson kinase's intrinsically disordered region plays essential roles in protein function and protein stability.

Cell communication and signaling : CCS - 24 Feb 2021

Rogers Edward M, Allred S Colby, Peifer Mark

Abstract excerpt

BACKGROUND: The non-receptor tyrosine kinase Abelson (Abl) is a key player in oncogenesis, with kinase inhibitors serving as paradigms of targeted therapy. Abl also is a critical regulator of normal development, playing conserved roles in regulating cell behavior, brain development and morphogenesis. Drosophila offers a superb model for studying Abl's normal function, because, unlike mammals, there is only a...

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Identifiers

PMID: 33627133
DOI: 10.1186/s12964-020-00703-w
PMCID: PMC7905622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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