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Article

A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1.

The Journal of biological chemistry - 8 Mar 2002

Sakai Yasunari, Furuichi Masato, Takahashi Masayuki, Mishima Masaki, Iwai Shigenori, Shirakawa Masahiro, Nakabeppu Yusaku

Abstract excerpt

MTH1 hydrolyzes oxidized purine nucleoside triphosphates such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP to monophosphates, and thus avoids errors caused by their misincorporation during DNA replication or transcription, which may result in carcinogenesis or neurodegeneration. This substrate specificity for oxidized purine nucleoside triphosphates was investigated by mutation analyses based on...

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Identifiers

PMID: 11756418
DOI: 10.1074/jbc.M110566200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1.PMID 11756418Read ↗

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