Article
Biochemical and physicochemical characterization of normal and variant forms of human MTH1 protein with antimutagenic activity.
Mutation research - 1 Sept 1997
Yakushiji H, Maraboeuf F, Takahashi M, Deng Z S, Kawabata S, Nakabeppu Y, Sekiguchi M
Abstract excerpt
8-Oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP) is produced during cellular metabolism, and its misincorporation into DNA causes mutation. Human cells possess an enzyme that hydrolyzes 8-oxo-dGTP to the corresponding nucleoside monophosphate, thereby preventing misincorporation o...
Topics
- Amino Acid Substitution
- Antimutagenic Agents
- Chemical Phenomena
- Chemistry, Physical
- Circular Dichroism
- DNA Repair Enzymes
- Enzyme Stability
- Escherichia coli
- Gene Expression Regulation
- Genetic Variation
- Hot Temperature