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Article

Biochemical and physicochemical characterization of normal and variant forms of human MTH1 protein with antimutagenic activity.

Mutation research - 1 Sept 1997

Yakushiji H, Maraboeuf F, Takahashi M, Deng Z S, Kawabata S, Nakabeppu Y, Sekiguchi M

Abstract excerpt

8-Oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP) is produced during cellular metabolism, and its misincorporation into DNA causes mutation. Human cells possess an enzyme that hydrolyzes 8-oxo-dGTP to the corresponding nucleoside monophosphate, thereby preventing misincorporation of 8-oxo-7,8-dihydroguanine into DNA. Sequence analyses of the MTH1 gene, encoding the...

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PMID: 9330614
DOI: 10.1016/s0921-8777(97)00025-6

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