Molecular genetics and structural biology of human MutT homolog, MTH1.

doi:10.1016/s0027-5107(01)00096-3

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Article

Molecular genetics and structural biology of human MutT homolog, MTH1.

Mutation research - 2 Jun 2001

Nakabeppu Y

Abstract excerpt

The human MTH1 gene located on chromosome 7p22 consists of 5 major exons. MTH1 gene produces seven types of mRNAs and the B-type mRNAs with exon 2b-2c segments direct synthesis of three forms of MTH1 polypeptides (p22, p21, and p18) by alternative initiation of translation, while the others encode only p18. In human cells, p18, the major form is mostly localized in the cytoplasm with some in the mitochondria. A...

Topics

Amino Acid Sequence
Animals
Base Sequence
DNA
DNA Repair Enzymes
Gene Expression Regulation, Enzymologic
Humans
Molecular Sequence Data
Phosphoric Monoester Hydrolases
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Protein Biosynthesis
Sequence Homology, Amino Acid
Substrate Specificity

Source

Open in PubMed

Identifiers

PMID: 11376687
DOI: 10.1016/s0027-5107(01)00096-3

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