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Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes.

DNA repair - 3 Nov 2002

Egashira Akinori, Yamauchi Kazumi, Yoshiyama Kaoru, Kawate Hisaya, Katsuki Motoya, Sekiguchi Mutsuo, Sugimachi Keizo, Maki Hisaji, Tsuzuki Teruhisa

Abstract excerpt

Oxidative damage of nucleotides within DNA or precursor pools caused by oxygen radicals is thought to play an important role in spontaneous mutagenesis, as well as carcinogenesis and aging. In particular, 8-oxodGTP and 2-OHdATP are potent mutagenic substrate for DNA synthesis. Mammalian MTH1 catalyzes hydrolysis of these mutagenic substrates, suggesting that it functions to prevent mutagenesis caused by these...

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Identifiers

PMID: 12531017
DOI: 10.1016/s1568-7864(02)00113-1

Genes

MSH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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