Article
Crystallization and preliminary X-ray analysis of human MTH1 with a homogeneous N-terminus.
Acta crystallographica. Section F, Structural biology and crystallization communications - 1 Jan 2013
Koga Yukari, Inazato Miyuki, Nakamura Teruya, Hashikawa Chie, Chirifu Mami, Michi Asuka, Yamashita Taku, Toma Sachiko, Kuniyasu Akihiko, Ikemizu Shinji, Nakabeppu Yusaku, Yamagata Yuriko
Abstract excerpt
Human MTH1 (hMTH1) is an enzyme that hydrolyses several oxidized purine nucleoside triphosphates to their corresponding nucleoside monophosphates. Crystallographic studies have shown that the accurate mode of interaction between 8-oxoguanine and hMTH1 cannot be understood without determining the positions of the H atoms, as can be observed in neutron and/or ultrahigh-resolution X-ray diffraction studies. The...
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