The influence of residue in the position of 116 on the inhibitory potency of TH588 for MTH1.

doi:10.1016/j.jmgm.2018.08.002

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Article

The influence of residue in the position of 116 on the inhibitory potency of TH588 for MTH1.

Journal of molecular graphics & modelling - 1 Oct 2018

Niu Rui-Juan, Zheng Qing-Chuan, Zhang Hong-Xing

Abstract excerpt

As one of the first-in-class inhibitor, TH588 was found to be efficient in the suppression of MutT homolog1 (MTH1). A recent work shows that the inhibitory potency of TH588 against human MTH1 (hsMTH1) is approximately 20-fold over that of mouse MTH1 (mmMTH1) and identifies residue in position 116 in MTH1 has an important contribution to TH588 affinity. But the effect of residue Leu or Met in position 116 on the...

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PMID: 30103119
DOI: 10.1016/j.jmgm.2018.08.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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