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Article

Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta.

Proceedings of the National Academy of Sciences of the United States of America - 19 Mar 2002

Shih David Q, Heimesaat Markus, Kuwajima Satoru, Stein Roland, Wright Christopher V E, Stoffel Markus

Abstract excerpt

Defects in pancreatic beta-cell function contribute to the development of type 2 diabetes, a polygenic disease that is characterized by insulin resistance and compromised insulin secretion. Hepatocyte nuclear factors (HNFs) -1alpha, -3beta, -4alpha, and Pdx-1 contribute in the complex transcripti...

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Identifiers

PMID: 11904435
DOI: 10.1073/pnas.062605899
PMCID: PMC122607

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11904435-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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